Glutathione Reductase antibody

Catalog No. ABIN5708412

The Rabbit Polyclonal anti-Glutathione Reductase antibody has been validated for WB, ELISA, ICC, IHC (p) and FACS. It is suitable to detect Glutathione Reductase in samples from Human, Rat and Mouse. There is 1 publication available.

Quick Overview for Glutathione Reductase antibody (ABIN5708412)

Target: Glutathione Reductase (GSR)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutathione Reductase antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-Glutathione Reductase Antibody

Purification: Antigen affinity purified

Immunogen: A recombinant human protein corresponding to amino acids K256-R522 was used as the immunogen for the Glutathione Reductase antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Glutathione Reductase antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,ICC (FFPE): 1-2 μg/mL,FACS: 1-3 μg/10^6 cells,Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Glutathione Reductase antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

References for anti-Glutathione Reductase antibody (ABIN5708412)

Kronstein-Wiedemann, Stadtmüller, Traikov, Georgi, Teichert, Yosef, Wallenborn, Karl, Schütze, Wagner, El-Armouche, Tonn: "SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism." in: Stem cell reviews and reports, (2022) (PubMed).

Target Details for Glutathione Reductase

Target: Glutathione Reductase (GSR)

Alternative Name: Glutathione Reductase / GSR

Background: Glutathione reductase (GR), also known as glutathione-disulfide reductase (GSR), is an enzyme that in humans is encoded by the GSR gene. This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.

UniProt: P00390

Pathways: Thyroid Hormone Synthesis, Cell RedoxHomeostasis